Longevity News

Get the latest news, press releases and clinical trials

Daily Longevity Science Briefing (September 24, 2025)

Brought to you by the Longevity Academy

Executive Summary

The most significant signal in the last 24 hours is the development of SystemsAge, a novel blood test from Yale University that can assess the biological age of 11 different organ systems from a single DNA methylation assay. This represents a major step towards personalized and preventive medicine, allowing for targeted interventions based on which organs are aging fastest. Another key advancement comes from a multi-species study in Nature Aging identifying herbal terpenoids (thymol and carvacrol) as potent activators of autophagy and mitophagy, demonstrating healthspan benefits in mice and worms. These findings highlight the growing interest in both high-resolution biomarkers and nutrition-based interventions in the longevity space.

What to watch next (7–30 days):

•Immorta Bio’s SenoVax™ IND Clearance: The company is in discussions with the FDA for a GMP demonstration run, the final step before IND clearance for their NSCLC trial. This will be a key milestone for their senolytic immunotherapy platform.

•Further Validation of SystemsAge: Expect follow-up studies and potential commercialization announcements for the SystemsAge test, as it is described as “ready to be used in the clinic today.”

•Preclinical data on MindWalk’s GLP-1 Program: Following their announcement, initial preclinical data on their AI-designed dual-pathway GLP-1 regimen for longevity is anticipated.

Ranked Top 5 Table

Rank	Title	Source	Published (PT)	Evidence Level	Domain Tag	Overall Score
1	SystemsAge: Organ-Specific Aging Blood Test	Nature Aging	2025-09-23 17:07:43	Human Observational	Biomarkers	4.5
2	Herbal Terpenoids Activate Autophagy and Mitophagy	Nature Aging	2025-09-24 11:08:24	Animal (Multi-species)	Autophagy/Mitochondria	3.9
3	Immorta Bio Reports Preclinical Activity of Senolytic Immunotherapy	PR Newswire	2025-09-24 06:02:00	Animal	Senolytics/Neuro-aging	3.3
4	Towards a Personalized Approach in Senolytic Trials	Nature Aging	2025-09-09 00:00:00	Expert Commentary	Clinical Trial Design	3.0
5	MindWalk Advances AI-Designed GLP-1 Program for Longevity	BioPharmaTrend	2025-09-23 22:00:00	Tool/Platform Dev.	AI-Drug Discovery	2.8

One-pager Summaries

#1. SystemsAge: Organ-Specific Aging Blood Test

What happened: Researchers from Yale University have developed a novel blood test called SystemsAge that can estimate the biological age of 11 different organ systems from a single DNA methylation assay. The test provides a granular, organ-by-organ view of the aging process, a significant advance over single-score biological age clocks.

Why it matters (impact): This test could revolutionize preventive and personalized medicine. By identifying which organs are aging most rapidly, clinicians can tailor interventions and monitor their effectiveness with high precision. The test is also more cost-effective than existing proteomic panels and is described as ready for clinical use.

Evidence level: Human Observational / Tool/Data

Study details:

•Species: Human

•n: Multiple large cohorts (specific numbers not reported)

•Effect size (if reported): Heart score strongly associated with time to coronary heart disease; lung score with time to lung cancer; brain score with cognitive function and time to stroke.

•Endpoints/biomarkers: DNA methylation, mortality, disease onset, organ-specific function.

Limitations/caveats:

•Requires further longitudinal validation in diverse populations.

•Clinical adoption and reimbursement will require regulatory approval and cost-benefit analysis.

•The study relies on secondary reporting, as the primary paper was not accessible.

Next milestone: Clinical implementation, regulatory submissions, and integration into preventive medicine workflows.

Primary link(s):

•https://longevity.technology/news/blood-test-reads-aging-organ-by-organ/

Conflicts/paywall:

•The primary Nature Aging paper is behind a paywall.

#2. Herbal Terpenoids Activate Autophagy and Mitophagy

What happened: A study published in Nature Aging identified thymol and carvacrol, compounds found in thyme and oregano, as potent activators of autophagy and mitophagy. The researchers used a high-content screening platform in zebrafish to identify these compounds.

Why it matters (impact): This study provides a mechanistic basis for the health benefits of common herbs and identifies food-grade compounds that could be used to promote healthspan. The findings open the door to nutrition-based interventions that mimic some of the benefits of fasting.

Evidence level: Animal (Multi-species) / In vitro

Study details:

•Species: Zebrafish, C. elegans, mice (SAMP8), human cells

•n: Not reported

•Effect size (if reported): Thymol supplementation prevented excess liver fat accumulation in a mouse model of diet-induced obesity and improved heat stress resilience in C. elegans.

•Endpoints/biomarkers: Autophagy flux, mitophagy, liver fat, muscle performance, epigenetic age.

Limitations/caveats:

•The research is preclinical, and human trials are needed to confirm the findings.

•The optimal dosage and long-term safety in humans are unknown.

Next milestone: Human clinical trials to assess the safety and efficacy of thymol and carvacrol supplementation for promoting healthspan.

Primary link(s):

•https://www.nature.com/articles/s43587-025-00957-4

Conflicts/paywall:

•None, the article is open access.

#3. Immorta Bio Reports Preclinical Activity of Senolytic Immunotherapy

What happened: Immorta Bio announced preclinical findings for their senolytic immunotherapy, SenoVax™, in a model of Chronic Traumatic Encephalopathy (CTE). The company also filed a patent for the unexpected link between cellular senescence and CTE.

Why it matters (impact): This research suggests a new therapeutic avenue for CTE, a neurodegenerative disease with no current disease-modifying treatments. It also highlights the potential for longevity-focused therapies to have applications across multiple disease areas, from oncology to neurodegeneration.

Evidence level: Animal

Study details:

•Species: Not specified (preclinical models)

•n: Not reported

•Effect size (if reported): SenoVax™-induced antibodies showed the most pronounced effects among the senolytics evaluated.

•Endpoints/biomarkers: CTE-associated signals, inflammation markers.

Limitations/caveats:

•The findings are preclinical and have not been peer-reviewed.

•The information comes from a company press release, which may contain bias.

•Limited methodological details were provided.

Next milestone: IND clearance for the SenoVax™ trial in non-small cell lung cancer (NSCLC), which will be the first clinical test of the platform.

Primary link(s):

•https://www.prnewswire.com/news-releases/immorta-bio-reports-preclinical-activity-of-senolytic-immunotherapy-senovax-in-a-chronic-traumatic-encephalopathy-cte-model-302565883.html

Conflicts/paywall:

•Company press release.

#4. Towards a Personalized Approach in Senolytic Trials

What happened: Leading researchers in the field of geroscience published a commentary in Nature Aging calling for a more personalized approach to senolytic clinical trials. They argue that while early trials have shown positive biological signals, clear evidence of efficacy is lacking, and a one-size-fits-all approach may not be optimal.

Why it matters (impact): This commentary could influence the design of future clinical trials for senolytics, leading to more targeted and effective therapies. It also highlights the need for better biomarkers to identify individuals who are most likely to respond to senolytic treatment.

Evidence level: Expert Commentary

Study details:

•Type: Expert commentary

•Authors: Sundeep Khosla, David G. Monroe, and Joshua N. Farr (Mayo Clinic/University of Arizona)

Limitations/caveats:

•This is an opinion piece, not primary research.

•The full text is behind a paywall.

Next milestone: Implementation of personalized, biomarker-driven approaches in upcoming senolytic clinical trials.

Primary link(s):

•https://www.nature.com/articles/s43587-025-00964-5

Conflicts/paywall:

•The article is behind a paywall.

#5. MindWalk Advances AI-Designed GLP-1 Program for Longevity

What happened: MindWalk, formerly ImmunoPrecise Antibodies, announced the development of an AI-designed, dual-pathway GLP-1 regimen for longevity. The program combines a GLP-1 receptor agonist with a companion therapeutic targeting cellular resilience.

Why it matters (impact): This program represents a novel, AI-driven approach to developing longevity therapeutics. The dual-pathway regimen could offer a more comprehensive approach to promoting healthspan than GLP-1 agonists alone.

Evidence level: Tool/Platform Development

Study details:

•Platform: Bio-Native AI platform with HYFT discovery engine and LensAI

•Methodology: In silico design

Limitations/caveats:

•The program is in the preclinical stage, with no human data available.

•The companion therapeutic and its target are undisclosed.

•The information comes from a company announcement.

Next milestone: Preclinical validation of the dual-pathway regimen and IND filing for clinical trials.

Primary link(s):

•https://www.biopharmatrend.com/news/mindwalk-advances-ai-designed-glp-1-program-with-dual-pathway-regimen-for-longevity-1394/

Conflicts/paywall:

•None.

Trends & Signals

A key trend emerging from today’s scan is the increasing focus on personalized and precision longevity medicine. The development of the SystemsAge test and the call for personalized senolytic trials both point to a move away from one-size-fits-all interventions. There is also a growing interest in nutrition-based approaches, as evidenced by the study on herbal terpenoids. Finally, the use of AI and machine learning in drug discovery for longevity continues to gain traction, as seen with MindWalk’s GLP-1 program.

Watchlist (near-term)

•Upcoming readouts from ongoing senolytic trials: Several clinical trials of senolytics are expected to report results in the coming months, which will be critical for validating the field.

•FDA action on Alzheimer’s blood tests: The FDA is expected to make decisions on several new blood tests for Alzheimer’s disease, which could have a major impact on the diagnosis and treatment of the disease.

•New preprints on partial reprogramming: The field of partial reprogramming is moving quickly, and new preprints with updated protocols and results are expected to be released soon.

Longevity Academy News

FOR IMMEDIATE RELEASE

Longevity Academy Launches Revolutionary Course:

Metformin for Longevity by Dr. DeAnn Bing

Bellevue, WA — January 1, 2025 — Longevity Academy, a leading platform dedicated to advancing education and resources in the field of healthy aging, is proud to announce the launch of its groundbreaking new course, “Metformin for Longevity” led by renowned expert Dr. DeAnn Bing. This comprehensive course explores the science, evidence, and practical strategies surrounding one of the most researched drugs in longevity science—metformin.

Dr. DeAnn Bing, a distinguished physician and longevity expert, brings over a decade of clinical experience and a passion for advancing the science of aging. The course is designed for healthcare professionals, longevity enthusiasts, and anyone interested in exploring the potential of metformin to enhance lifespan and healthspan.

About the Course: The Benefits of Metformin for Longevity

The course offers a deep dive into the science, mechanisms, and practical application of metformin in the context of healthy aging. Featuring meticulously designed modules, the curriculum covers:

Module 1: Introduction to Longevity Science

Foundations of longevity, lifespan, and healthspan.
Biological pathways like mTOR, AMPK, and autophagy.
Role of lifestyle factors and medication in aging strategies.

Module 2: Metformin – Origins, Mechanism, and Safety Profile

History of metformin and its medical use.
Mechanisms of action, including effects on glucose metabolism and mitochondrial health.
Safety considerations and guidelines for use.

Module 3: Scientific Evidence of Metformin’s Longevity Benefits

Insights from preclinical and human studies.
Key findings from the TAME Trial (Targeting Aging with Metformin).

Module 4: Metformin vs. Other Longevity Interventions

Comparisons with drugs like rapamycin and resveratrol.
Synergies with lifestyle interventions like fasting and exercise.

Module 5: Practical Aspects of Metformin Use

Dosing strategies, timing, and long-term use considerations.
Managing side effects and monitoring health markers.

Module 6: Ethical, Regulatory, and Future Perspectives

Ethical questions surrounding drug use for aging.
Regulatory challenges and emerging research directions.

Module 7: Case Studies and Personal Testimonials

Real-world examples and healthcare professional insights.

Module 8: Conclusion and Action Steps

Personalized longevity planning with an option for a consultation with Dr. Bing.

What Makes This Course Unique?

Dr. Bing’s course bridges the gap between cutting-edge science and practical application. By blending in-depth scientific evidence with actionable steps, participants will:

Understand metformin’s mechanisms and safety profile.
Explore its synergies with lifestyle interventions.
Learn how to incorporate metformin into personalized longevity strategies.
Gain access to exclusive resources and support for ongoing learning.

Who Should Enroll?

This course is ideal for:

Healthcare providers interested in integrating longevity medicine into their practice.
Individuals passionate about healthy aging and proactive health management.
Researchers and students eager to expand their understanding of pharmacological longevity interventions.

Enrollment Details

Enrollment for “Metformin for Longevity” is now open. Participants will receive lifetime access to the course content, updates, and a complimentary consultation with Dr. Bing for personalized guidance.

To learn more or enroll in the course, visit www.LongevityTrainingAcademy.com.

About Longevity Academy

Longevity Academy is a global leader in education for healthy aging and lifespan extension. By offering cutting-edge courses, tools, community and coaching, the Academy empowers individuals and professionals to unlock the secrets of living longer, healthier lives.

For media inquiries, please contact: Valerie Merrill, PR
Email: press@longevitytrainingacademy.com
Phone: 319-257-9757

Unlock the Science of Longevity with Dr. DeAnn Bing and Longevity Academy!

———————————————————————–

FOR IMMEDIATE RELEASE

The Longevity Academy to Unveil new book “The Longevity Scorecard” at LongevityFest 2024 in Las Vegas

A Revolutionary Guide to Tracking and Optimizing Health and Lifespan

Seattle, WA — December 10, 2024 — The Longevity Academy, is set to launch its highly anticipated book, “The Longevity Scorecard: Unlocking Your Path to a Longer, Healthier Life,” at the prestigious LongevityFest Conference in Las Vegas on December 13, 2024. The book release will coincide with the launch of Longevityscore.org, marking a milestone moment in the field of longevity education and tracking.

A Transformative Tool for Health and Longevity

“The Longevity Scorecard”, written by Longevity Academy CEO, Richard Diamond, introduces a groundbreaking approach to personal health and wellness, offering readers a comprehensive guide to tracking and improving key aspects of their lives. From nutrition and exercise to mental well-being and medical care, this innovative book empowers individuals to take control of their health through an easy-to-use, customizable scorecard system.

The book brings together cutting-edge longevity science, actionable strategies, and motivational tools to help readers not only understand the factors that influence lifespan but also actively measure and enhance their progress. The book covers:

The science behind aging and longevity.
Practical methods to track physical, mental, and social health with a customizable Longevity Scorecard.
Real-life case studies demonstrating the scorecard’s impact.

“Longevity isn’t just about living longer—it’s about living better,” said Diamond. “This book bridges the gap between theory and action, equipping readers with the tools to thrive at every stage of life.”

Key Features of “The Longevity Scorecard”

Science-Based Insights: A deep dive into the biological and lifestyle factors that influence longevity.
Customizable Tracking Tool: Step-by-step guidance on creating a personalized scorecard tailored to individual goals.
Practical Strategies: Chapters dedicated to nutrition, exercise, sleep, stress management, and preventative healthcare.
Real-Life Inspiration: Success stories and case studies from individuals who have transformed their lives using the scorecard.

About the Author

Richard Diamond is the CEO of The Longevity Academy, a platform dedicated to educating and empowering individuals to live healthier, happier and longer lives. With a focus on research-based strategies, The Longevity Academy offers resources, coaching, and community support to help individuals achieve optimal health and well-being. Diamond is also a Certified Longevity Coach and has over 20 years of experience in the health and wellness sector.

Book Launch Details

The official book launch will take place during LongevityFest 2024, one of the largest gatherings of health and wellness experts, biohackers, and longevity enthusiasts. Diamond will be available for interviews at LongevityFest.

When: December 13, 2024
Where: LongevityFest Conference, Las Vegas, NV

Availability

“The Longevity Scorecard” will be available for FREE on our website starting December 13, 2024, at www.longevitytrainingacademy.com, and online through Amazon, and at select bookstores nationwide for $19.97.

Join the Movement

To learn more about the book, the scorecard, and The Longevity Academy, visit Longevity Academy. Follow the conversation on social media using #LongevityScore, #LiveBetterLonger, #LongevityFest and #LongevityAcademy.

About Longevity Academy:
The Longevity Academy is a global leader in longevity education, coaching and community. The platform offers a range of resources, including FREE beginner longevity courses along with advanced courses, group and 1 on 1 longevity coaching, and community support, to help individuals achieve healthier, longer lives.

For media inquiries, interviews, or advanced copies of “The Longevity Scorecard,” please contact: hello@longevitytrainingacademy.com.

Longevity Academy News

FOR IMMEDIATE RELEASE

Longevity Academy Launches Advanced Course on NAD+ Therapy for Health and Longevity

Bellevue, WA – The Longevity Academy is excited to announce the launch of a groundbreaking new course, “Exploring NAD+ Therapy for Health and Longevity,” created and presented by Dr. DeAnn Bing, of Atlanta, GA. The course is designed for healthcare professionals, researchers, and wellness enthusiasts interested in the science behind NAD+ (Nicotinamide Adenine Dinucleotide) and its potential role in aging and disease prevention.

The comprehensive course provides participants with an in-depth understanding of NAD+’s biological significance, its therapeutic applications, and the latest research in the field. As NAD+ emerges as a promising tool for extending lifespan and improving health, this course offers a unique opportunity to explore its potential in a structured and evidence-based way.

Course Objectives:

Understand the biological role of NAD+ in cellular processes.
Explore the potential benefits of NAD+ therapy for extending life and improving health.
Evaluate the risks and ethical considerations associated with NAD+ therapy.
Review current research and clinical trials related to NAD+ therapy.
Develop practical knowledge of NAD+ supplementation and therapy applications.
Determine if NAD+ is right for you.

Course Structure: The course is divided into twelve modules, each focusing on critical aspects of NAD+ research, therapy, and practical application:

Module 1: Introduction to NAD+
Module 2: Biological Role of NAD+
Module 3: NAD+ and Aging
Module 4: Potential Anti-aging Benefits of NAD+ Therapy
Module 5: Health Benefits of NAD+ Therapy
Module 6: NAD+ Role in Neurodegenerative Diseases
Module 7: NAD+ Role in Cardiovascular Health
Module 8: NAD+ and Immune Function
Module 9: Clinical Applications of NAD+ Therapy
Module 10: NAD+ Regulatory and Ethical Concerns
Module 11: Longevity Experts’ Opinions
Module 12: Summary

Who Should Attend? This course is ideal for medical professionals, biohackers, researchers, and anyone interested in the latest advances in anti-aging science and regenerative medicine. Participants will gain both theoretical knowledge and practical skills in NAD+ therapy, making them well-equipped to integrate this cutting-edge approach into their personal practices.

Why NAD+ Therapy Matters NAD+ plays a critical role in cellular processes, including DNA repair, metabolism, and energy production. As we age, NAD+ levels naturally decline, contributing to aging and disease. Research has shown that boosting NAD+ levels can extend lifespan, improve overall health, and mitigate age-related conditions. This course aims to bridge the gap between science and practice, offering attendees a detailed understanding of how to leverage NAD+ therapy to optimize health and longevity.

Enrollment Information The course is now open for enrollment at Longevity Academy for FREE. For more information or to register, please visit https://longevitytrainingacademy.com/nad-therapy-course/ or contact us at hello@longevitytrainingacademy.com.

About The Longevity Academy The Longevity Academy is a leading educational portal dedicated to providing advanced education on health, longevity, and anti-aging science. Our mission is to democratize longevity and empower individuals with the knowledge and tools to optimize health and extend lifespan through scientifically backed strategies.

About Dr. DeAnn Bing Dr. DeAnn Bing is a board-certified Internal Medicine physician located in Atlanta, GA and has been practicing medicine for over 10 years. She is a leading expert in longevity medicine as well as anti-aging strategies.

Media Contact: hello@longevitytrainingacademy.com

Thank you for the amazing masterclass about the Hormone Replacement Therapy. I’m watching the rest of the courses now and look forward to learning more.

Alicia C., Owner, Executive Yoga & Pilates

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