Bio:Matt Kaeberlein is a renowned researcher and professor of Pathology at the University of Washington, where his work focuses on aging and age-related diseases. With a deep commitment to understanding the biology of aging, Kaeberlein has made significant contributions to the field, particularly in identifying genetic and molecular mechanisms that influence longevity and healthspan.
Supplement Stack
Rapamycin:(6 mg of rapamycin once a week)
Reason for taking this supplement:Kaeberlein is known for his research on rapamycin, a drug originally used as an immunosuppressant. Studies have shown that rapamycin can extend lifespan in various model organisms, and Kaeberlein himself has experimented with it, using it in a low dose to potentially mimic some of its beneficial effects on aging while minimizing side effects.
Resveratrol:(500 mg per day)
Reason for taking this supplement:This compound is found in red wine and has been studied for its potential anti-aging properties. Resveratrol is thought to activate sirtuins, a group of proteins involved in cellular regulation and longevity. Kaeberlein has investigated resveratrol’s effects on healthspan and lifespan in model organisms.
Metformin:(500 mg twice a day)
Reason for taking this supplement:Commonly used to manage type 2 diabetes, metformin has garnered interest for its potential benefits beyond glucose control. Research suggests it may have anti-aging effects and help improve healthspan. Kaeberlein has explored the use of metformin for its potential to mimic the effects of caloric restriction, which is known to extend lifespan in various organisms.
NAD+ Precursors (e.g., NMN or NR):( 250 mg to 500 mg per day of NMN)( If using NR, doses in the range of 300 mg to 500 mg per day )
Reason for taking this supplement:NAD+ is a crucial molecule involved in energy metabolism and cellular repair. Supplementing with precursors like Nicotinamide Mononucleotide (NMN) or Nicotinamide Riboside (NR) may boost NAD+ levels and support cellular health. Kaeberlein has shown interest in these compounds for their potential to enhance cellular function and delay aging processes.
Curcumin:(500 mg per day)
Reason for taking this supplement:Derived from turmeric, curcumin is known for its anti-inflammatory and antioxidant properties. Kaeberlein has noted its potential benefits for overall health and its role in reducing inflammation, which is a key factor in aging and age-related diseases.
Omega-3 Fatty Acids:(1,000 mg to 2,000 mg of fish oil per day)
Reason for taking this supplement:Found in fish oil, omega-3 fatty acids are known for their anti-inflammatory and cardiovascular benefits. They may contribute to overall health and longevity by supporting heart health and reducing inflammation.